Review <p>Although adenosine (ADO) has been shown to have beneficial effects against tissue injury after myocardial ischaemia, the controversy still remains regarding the optimal timing, dose, temperature, method of ADO administration and duration of exposure to the drug. This study investigates the cardioprotective effect of exogenous ADO pretreatment as an adjunct to 1 mmol l-1 ADO cold (12 &deg;C) blood cardioplegia during heart valve replacement surgery.</p> Adenosine • Cardiopulmonary bypass 0 0 http://www.iscs.org.ir/journals/vol.3/no.5/263/